Introduction: The 2017 Indonesian Demographic and Health Survey (IDHS) shows that male ado lescents' prevalence of condom use is relatively low during their first sexual intercourse. The present study aimed to ascertain the determinants of condom use by male adolescents in Indonesia during their first sexual intercourse. Material and methods: A quantitative analysis with a cross-sectional approach of secondary data from IDHS 2017 was used in this research. Sample used included 980 male adolescents aged 15-24 years, unmarried, and have had a sexual intercourse. Determinant analysis was conducted with multi variable binomial logistic regression analysis. Results: The results showed a greater tendency of condom use during first sexual intercourse by male adolescents with a higher education level (AOR: 2.47; 95% CI: 1.41-4.34%), age of ≥ 18 years (AOR: 1.48; 95% CI: 1.09-2.00%), with a positive attitude towards condom use (AOR: 2.08; 95% CI: 1.40-3.11%), and exposed to all mass media (AOR: 2.00; 95% CI: 1.43-2.80%). However, a reverse trend occurred if f irst sexual partner was not a sex worker, such as a friend or girlfriend (AOR: 0.29; 95% CI: 0.15-0.56%). Conclusions: Interventions in the control of STIs, including HIV/AIDS, through condom use in male adolescents, should be focused on the age group of < 18 years, with lower secondary education level, and among the most at-risk individuals. These efforts can be conducted through comprehensive, com munity-based reproductive health and sexuality education outside school, and based on the curriculum applied in these institutions.